cytoplasmic inclusion การใช้

• This protein accumulation forms proteinaceous cytoplasmic inclusions called Lewy bodies.
• A definitive diagnosis can only be made pathologically on finding abundant glial cytoplasmic inclusions in the central nervous system.
• Intracellular deposition of misfolded protein aggregates into ubiquitin-rich cytoplasmic inclusions is linked to the pathogenesis of many diseases.
• The misfolded form of TDP-43 forms cytoplasmic inclusions in afflicted neurons, and is found depleted in the nucleus.
• NSP2 is an RNA-binding protein that accumulates in cytoplasmic inclusions ( viroplasms ) and is required for genome replication.
• The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration.
• Akaline and acid treatments can be effective companions with an SDS treatment due to their ability to degrade nucleic acids and solubilize cytoplasmic inclusions.
• Why these aggregates form despite the existence of cellular machinery to recognize and degrade misfolded protein, and how they are delivered to cytoplasmic inclusions, are not known.
• PRSV has a different host range, different serological properties, and no nucleotide sequence homology with WMV . WMV also has different cytoplasmic inclusion bodies that can differentiate it from PRSV-W.
• A classical Lewy body is an eosinophilic cytoplasmic inclusion consisting of a dense core surrounded by a halo of 10-nm-wide radiating fibrils, the primary structural component of which is alpha-synuclein.
• This is seen in infections caused by EPEC subgroup " Escherichia coli ", in celiac disease, and microvillus inclusion disease ( an inherited disease characterized by defective microvilli and presence of cytoplasmic inclusions of the cell membrane other than the apical surface ).
• In a recent comparison of lymphocystis histopathology of four unrelated marine species, lesions consistently associated with lymphocystis included hypertrophied cells displaying irregular nuclei, basophilic cytoplasmic inclusion bodies that stained positively via Feulgen and Mann's reaction and Periodic acid-Shiff ( PAS )-positive hyaline capsules.
• Through clinical studies, researchers identified that TFG mutations on chromosome 3q13.2 causes HMSN-P . " The presence of TFG / ubiquitin-and / or TDP-43-immunopositive cytoplasmic inclusions in motor neurons and cytosolic aggregation composed of TDP-43 in cultured cells expressing mutant TFG indicate a novel pathway of motor neuron death"